Prevalence of Pancreatic Secretory Trypsin Inhibitor (SPINK1) gene mutation in patients with acute alcohol pancreatitis (AAP) compared to alcoholics and healthy controls

Objectives Approximately 10% of heavy alcohol users develop acute pancreatitis (AP). This suggests that additional triggers are required to initiate the inflammatory process. Genetic susceptibility contributes to the development of AP and for example SPINK1 mutation is a documented risk factor for the disease. However, only few genetic studies comparing AP patients and heavy alcohol users without pancreatitis exist. Our aim was to study the prevalence of SPINK1 (N34S) mutation in patients with acute alcohol pancreatitis (AAP) compared to heavy alcohol users who had never suffered an episode of pancreatitis.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Anssi Nikkola, Karl-Heinz Herzig, Kari M äkelä, Shivaprakash Jagalur Mutt, Terho Lehtimäki, Mika Kähönen, Olli Raitakari, Ilkka Seppälä, Pihla Paakkanen, Hanna Seppänen, Isto Nordback, Juhani Sand, Johanna Laukkarinen Tags: 4. Genetics in pancreatic diseases Source Type: research