DPC4, P53 and MTAP expression in patients with locally advanced and metastastic pancreatic cancer

Objectives Whole-genome sequencing studies have given extensive insight in the genetic landscape of resectable pancreatic cancer. However, little is known about the molecular features of locally advanced (LAPC) and metastatic pancreatic cancer, which represents 80% of the patients at time of diagnosis. P53 and DPC4 are frequently mutated genes in pancreatic cancer and are also suggested to have clinical implications. Moreover, a homozygous deletion of the gene coding for methylthiadenosine phosphorylase (MTAP) has become a subject of interest because of its potential for therapeutic targeted therapy.
Source: Pancreatology - Category: Gastroenterology Authors: Tags: 4. Genetics in pancreatic diseases Source Type: research