Formulation and evaluation of embelin loaded pectin nanoparticles for the treatment of diabetes

Objectives Embelin exhibited insulin sensitizing effect through adipose tissue specific partial agonist of PPAR γ and activated glucose transport through translocation and activation of GLUT4 mediated by insulin dependent PI3k/p-Akt pathway in epidermal adipose tissue. It also protected β-cells by scavenging free radicals and alleviated dyslipidemia in insulin resistant animal model. So in present study we developed embelin loaded controlled release nanoparticles using pectin.
Source: Pancreatology - Category: Gastroenterology Authors: Tags: 5. Diabetes and the pancreas Source Type: research