A multidisciplinary approach to familial pancreatic cancer enriches the proportion of patients with genetically confirmed pancreatic cancer susceptibility

Objectives The risk of pancreatic cancer(PC)increases with the number of affected first degree relatives(FDR)from 4-7% with only one or two relatives to 17-32% with three or more.FPC accounts for 4-10% of all PCs, with a germline mutation described in 5-10% of cases. In absence of other cancers to suggest one of the known syndromes associated with PC,genetic testing and instrumental screening is rarely offered to FPC families.This may change with the emergence of genetic tests that use panels of cancer susceptibility genes and with screening of high risk individuals.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Giulia Martina Cavestro, Alessandro Mannucci, Raffaella Alessia Zuppardo, Stefano Crippa, Michele Reni, Silvia Zanon, Milvia Zambetti, Maria Grazia Patricelli, Annalisa Russo Raucci, Milena di Leo, Francesco de Cobelli, Paolo Giorgio Arcidiacono, Luca Gia Tags: 8. Pancreatic Cancer I Source Type: research