Tissue characterization of components of the antigen processing machinery in pancreatic ductal adenocarcinoma

Objectives The molecules composing the antigen processing machinery (APM) have a crucial role in tumor immune evasion. Defects at different steps of the APM correlate with increased disease aggressiveness and worse clinical outcome in many solid tumors. With the aim of describing novel prognostic biomarkers to better stratify tumor patients, we have characterized the expression of different components of the APM in pancreatic ductal adenocarcinoma (PDAC) specimens.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Greta Donisi, Giovanni Francesco Castino, Giovanni Capretti, Nina Cortese, Francesca Gavazzi, Cristina Ridolfi, Gennaro Nappo, Giulia Maggi, Cristina R. Ferrone, Soldano Ferrone, Federica Marchesi, Alessandro Zerbi Tags: 9. Experimental pancreatic cancer I Source Type: research