High PRDX3 expression is associated with pancreatic adenocarcinoma aggressiveness and can be targeted by a novel therapeutic strategy

Objectives Ageing and inflammation have been linked to the development of pancreatic adenocarcinoma (PDAC). PDAC has a dense and poorly vascularised stroma resulting in severe hypoxia. This suggests that oxidative stress plays a major role in tumor development and aggressiveness. The aim of this study was to assess oxidative stress-related protein damage and its role in PDAC.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Jerome Raffenne, Fernando A. Martin, Marina Conta, Alain Sauvanet, Pascal Hammel, Pierre Bedossa, Valerie Paradis, Anne Couvelard, Jerome Cros Tags: 9. Experimental pancreatic cancer I Source Type: research