Effect of cathepsin inhibition on metabolism and polarization of tumor-associated macrophages

Objectives Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive stroma reaction. Stroma-infiltrating immune cells such as tumor-associated macrophages (TAM) play an important role in regulating tumor progression and chemoresistance due to their production and secretion of numerous immune mediators including cathepsins. Accumulating evidence suggests that cathepsins play an important role as modulators of the TAM phenotype.
Source: Pancreatology - Category: Gastroenterology Authors: Tags: 9. Experimental pancreatic cancer I Source Type: research