Overall cellularity but not acellular stroma deposition increases gemcitabine accumulation in a genetically engineered mouse model of pancreatic cancer

Objectives The role of the activated stroma in PanIN-PDAC progression and in drug delivery is still a matter of debate. SPARC (Secreted Protein Acidic and Rich in Cysteine) has been implicated in collagen deposition and is predominantly expressed by cancer associated fibroblasts (CAFs).

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Iswarya Ramu, Robert Goetze, Melanie Patzak, Philipp Str öbel, Bence Sipos, Frances Richards, Duncan Jodrell, Elisabeth Hessmann, Volker Ellenrieder, Albrecht Neesse Tags: 9. Experimental pancreatic cancer I Source Type: research