Are extracellular vesicles able to control human pluripotent stem cell fate?

Objectives Exosomes have been identified as mediators of cell-to-cell communication by delivering bioactive molecules.Cancer derived exosomes not only influence the invasive potentials of local neighboring cells, but also affect distant tissues.Induced pluripotent stem cells (iPSCs), obtained from adult somatic cells carry embryonic stem cells (ESC) properties, such as self renewal and ability to differentiate into all three embryonic germ layers.We asked whether the secretome of human pancreatic tumor cells selectively reprogram stem cells or progenitors to a pancreatic pre-malignant state.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Etienne Buscail, Pascaline Quincy, Celine Gounou, Anne-Aurelie Raymond, Isabelle Lamrissi-Garcia, Isabelle Moranvillier, Frederic Saltel, Fran çois Moreau-Gaudry, Laurence Chiche, Aurelie Bedel, Alain Brisson, Sandrine Dabernat Tags: 9. Experimental pancreatic cancer I Source Type: research