Inhibition of NF-kB decreases self-renewal in CD133 positive pancreatic cancer cells

Objectives Introduction: Pancreatic Cancer is a lethal malignancy with a dismissal 5-year survival rate of 7%. One of the main factors that makes pancreatic cancer a very difficult disease to treat is the presence of a sub population of cells, known as the cancer stem cells. These cancer stem cells have high expression of self-renewal genes namely SOX2, OCT4 and NANOG which confers them the ability to "self-renew". NF kB is a pro survival pathway which has been shown by numerous reports to be over expressed in Pancreatic Cancer.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Nikita Sharma, Patricia Dauer, Vineet Kumar Gupta, Kousik Kumar Kesh, Roey Hadad, Vikas Dudeja, Ashok Saluja, Sulagna Banerjee Tags: 9. Experimental pancreatic cancer I Source Type: research