Kras downstream signaling in pancreatic ductal adenocarcinoma

Objectives To investigated the functions of oncogenic Kras downstream signaling pathways in pancreatic ductal adenocarcinoma (PDAC). Oncogenic Kras initiates the carcinogenesis via different signalling cascades including the PI3K-Pdk1 and the Raf-Mek-Erk pathway. We could show previously that the deletion of 3-phosphoinositide-dependet protein kinase 1 (Pdk1) completely blocks the formation of precursor lesions such as pancreatic intraepithelial lesions (PanIN) and PDAC in a pancreatic cancer mouse model.

https://www.pancreatology.net/article/S1424-3903(18)30301-6/fulltext?rss=yes

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Hongkai Yan, Nina Sch önhuber, Christian Veltkamp, Barbara Seidler, Roland M. Schmid, Günter Schneider, Dieter Saur Tags: 9. Experimental pancreatic cancer I Source Type: research