Bile acids increase MUC4 expression in pancreatic ductal adenocarcinoma

Objectives Pancreatic cancer (PC) is the fourth leading cause of cancer death and accounts for 7% of all cancer death.Notably,70% of PC occurs in the head of the pancreas which reaching a critical size and can blocks the main pancreatic duct and the common bile duct,thus increasing the concentration of bile acids (BA's) in the serum.It is hypothesized that levels of BA's increases the tumorgenic potential of PC cells by changing the expression of oncogenic mucins. MUC4 is a trans-membrane glycoprotein that is overexpressed in pancreatic ductal adenocarcinoma (PDAC) but not in the normal pancreatic tissues.
Source: Pancreatology - Category: Gastroenterology Authors: Tags: 9. Experimental pancreatic cancer I Source Type: research