A novel protocol for isolation and culture of primary pancreatic stellate cells within the context of their tissue of origin

Objectives The contradicting evidence in scientific research thus far on the effect and the role of pancreatic stellate cells on pancreatic cancer cannot be ignored anymore. It is of no doubt that the stellate cells together with other cancer-associated fibroblasts are the main orchestrators of the unique desmoplastic reaction seen in the stroma of the pancreatic cancer. Since the identification and extraction of pancreatic stellate cells almost two decades ago, gathering evidence has been that they play a key role in promoting the proliferation invasion and spread of cancer cells in PDAC as well as provide a stem cell niche.
Source: Pancreatology - Category: Gastroenterology Authors: Tags: 9. Experimental pancreatic cancer I Source Type: research