L-histidine but not other basic amino acid-induced pancreatitis in mice involves inositol trisphosphate receptor signalling and mitochondrial permeability transition

Objectives The basic amino acids L-arginine, L-ornithine and L-lysine can trigger acute pancreatitis (AP), but the mechanisms of toxicity are not well understood. We compared a newly developed L-histidine model of AP with standard L-arginine and L-ornithine models and found remarkable differences in the mechanisms of toxicity and pharmacological profiles.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Xiaoying Zhang, Linbo Yao, Na Shi, Xinmin Yang, Dan Du, Tingting Liu, Peter Szatmary, Rajarshi Mukherjee, Qing Xia, David Criddle, Wei Huang, Michael Chvanov, Alexey Tepikin, Robert Sutton Tags: Session 7. Progress in experimental pancreatitis - free papers Source Type: research