Adaptive immune response during acute pancreatitis is regulated by NLRP3 inflammasome activation via interleukin 18

Objectives The Systemic Inflammatory Response Syndrome (SIRS) is responsible for the severity and mortality in acute pancreatitis. Inflammasome activation within phagocytosing macrophages via damage-associated-molecular-patterns (DAMPs) could play an important role for the cross talk between the innate and adaptive immune system. Here we investigated the cross talk between pancreatic macrophages and T-cells via inflammasome-mediated cytokine response.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Matthias Sendler, Cindy van den Brandt, Juliane Glaubitz, Anika Wilden, F. Ulrich Weiss, Janine Golchert, Georg Homuth, Lukas Bossaller, Julia Mayerle, Markus M. Lerch Tags: Session 7. Progress in experimental pancreatitis - free papers Source Type: research