Mast cell stabilizers can serve as “co-analgesics” in acute and chronic pancreatitis

Objectives Severe abdominal pain is the leading symptom of acute (AP) and chronic pancreatitis (CP). We could recently show that neuropathic pain in CP is linked to perineural accumulation of acitivated mast cells. Therefore, we now hypothesized that inhibition/stabilization of mast cells may lead to improvement of pancreatitis-associated pain and tested mast cell stabilizers (i.e., ketotifen and cromoglycate) as potential “co-analgesics” in AP and CP.
Source: Pancreatology - Category: Gastroenterology Authors: Tags: Session 7. Progress in experimental pancreatitis - free papers Source Type: research