Increased 1-deoxy-sphingolipids in diabetes are cytotoxic for pancreatic acinar cells

Objectives Exocrine pancreatic insufficiency and exocrine function alterations are frequent in diabetes mellitus (DM) patients with a prevalence up to 50%. DM is associated with increased plasma levels of 1-deoxy-sphingolipids (1-dSLs), atypical sphingolipids with demonstrated cytotoxicity on several cell types. Our results showed that 1-dSLs are also cytotoxic for acinar cells in vitro. Furthermore, the high level of 1-dSLs in diabetic animal model aggravated acinar cell damage whereas lowering levels of 1-dSLs improved cell deterioration.
Source: Pancreatology - Category: Gastroenterology Authors: Tags: Session 7. Progress in experimental pancreatitis - free papers Source Type: research