Gene, environment and Surgical risk of diabetes mellitus in patients with chronic pancreatitis from the North American pancreatitis study 2 (NAPS2)

Objectives Diabetes Mellitus (DM) occurs in a third of patients with chronic pancreatitis (CP). Type 3c DM (T3cDM) represents a type of DM caused by dysfunction or destruction of the islets from exocrine pancreatic disease or surgical removal. However, some individuals may have islets that are more sensitive to DM than others, resulting in early DM in some and resistance to DM in others as in Type 2 DM (T2DM). Our Aim was to evaluate patients in the North American Pancreatitis Study 2 (NAPS2) with CP and with and without DM to determine associations with known genes and environmental risk factors.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Tanvi Nagpal, Melina Bellin, Dhiraj Yadav, Phil Greer, Mark O. Goodarzi, David Whitcomb, for the NAPS2 consortium and the NIDDK/NCI Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer Tags: Session 9. Dieabetes and the pancreas Source Type: research