Depletion of the gut microbiota decreases pancreatic cancer burden by modulating the immune system

Objectives The gut microbiome significantly outnumbers the human genome. While the latter is non-modifiable, the microbiome changes with nutrition, age, geography and disease-state. Multiple cancers, including pancreatic ductal adenocarcinoma (PDAC), present with changed ‘dysbiotic’ gut microbiota. Whether this dysbiotic state promotes cancer or is a neutral-bystander is unclear. We investigated this relationship in multiple preclinical models of pancreatic and other cancers.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Vrishketan Sethi, Saba Kurtom, Mohammad Tarique, Shweta Lavania, Zoe Malchiodi, Leonor Hellmund, Bhuwan Giri, Bharti Garg, Sundaram Ramakrishnan, Sulagna Banerjee, Sabita Roy, Ashok Saluja, Vikas Dudeja Tags: Session 11. Molecular mechanisms of pancreatic cancer - free papers Source Type: research