Impact of cytosolic 5'-nucleotidase 1A on chemotherapeutic resistance in pancreatic cancer

Objectives The nucleoside analogue gemcitabine, still a standard chemotherapeutic agent in metastatic pancreatic cancer, is administered as prodrug and requires sequential phosphorylation to be activated. Cytosolic 5 ’-nucleotidase 1A (Nt5c1A) catalyzes the dephosphorylation of nucleoside monophosphates, thus reversing the initial phosphorylation of gemcitabine.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Melanie S. Patzak, Elisabeth Hessmann, Vijayalakshmi Kari, Julia Kitz, Shilpa Patil, Frances M. Richards, Duncan I. Jodrell, Steven A. Johnsen, Volker Ellenrieder, Albrecht Neesse Tags: Session 11. Molecular mechanisms of pancreatic cancer - free papers Source Type: research