Reversing pancreatic cancer metastasis through pharmacological targeting of pancreatic stellate cell's dialog with M2 macrophages

Objectives Pancreatic ductal adenocarcinoma (PDAC) presents an exuberant stroma. Stromal activated pancreatic stellate cells (PSC) secrete soluble and extracellular matrix (ECM) proteins that promote cancer cell aggressiveness.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: R émi Samain, Julia Rochotte, Stéphanie Cassant-Sourdy, Aurélie Perraud Perraud, Muriel Mathonnet, Herbert Schmid, Yvan Martineau, Stéphane Pyronnet, Christine Jean, Corinne Bousquet Tags: Session 11. Molecular mechanisms of pancreatic cancer - free papers Source Type: research