Epigenetic mechanisms drive cellular reprogramming in pancreatic carcinogenesis
Objectives Pancreatic acinar cells show an immense cellular plasticity in pancreatitis and pancreatic cancer development. Compared to differentiated acinar cells, progenitor-like acinar-to-ductal metaplasia (ADM) and embryonic acinar cells are highly susceptible towards oncogenic Kras-driven cellular transformation. Given that inflammation-triggered ADM occurs in the absence of genetic mutations, associated transcriptional changes are likely induced by epigenetic modifications. To define epigenetic reprogramming in pancreatic tumor development, we investigated global changes in histone modifications in an in vitro carcinogenic sequence.
Source: Pancreatology - Category: Gastroenterology Authors: Simone Benitz, Ujjwal M. Mahajan, Stefan Czemmel, Sven Nahnsen, G üralp Ceyhan, Julia Mayerle, Christoph W. Michalski, Jörg Kleeff, Ivonne Regel Tags: Session 11. Molecular mechanisms of pancreatic cancer - free papers Source Type: research