Enhanced photocytotoxicity induced by a platinum diimine complex employing amine-functionalized magnetite-silica nanocomposites as delivery vehicles

Photodynamic therapy (PDT) is a therapeutic modality for cancer diagnosis and treatment of various types of tumors [1]. PDT usually consists of three components: a photosensitizer, light, and tissue oxygen. The light-activated photosensitizer transfers its excited-state energy to the surrounding oxygen, leading to the generation of cytotoxic singlet oxygen or other reactive oxygen species in targeted cells and consequently to cancer cell death and tissue devastation. In comparison with the conventional cancer treatment methods, PDT has some unique advantages such as minimal invasiveness and repeatability without cumulative toxicity, thus has become a prospective alternative to conventional anticancer therapies [2].
Source: Photodiagnosis and Photodynamic Therapy - Category: Laser Surgery Authors: Source Type: research