Selenium, Vitamin C and N-Acetylcysteine do not Reduce the Risk of Acute Kidney Injury after Off-Pump CABG: a Randomized Clinical Trial

Objective: The aim of this study was to investigate the impact of perioperative
administration of N-acetylcysteine, selenium and vitamin C on the incidence
and outcomes of acute kidney injury after off-pump coronary bypass graft
surgery.Methods: 291 patients requiring elective off-pump coronary bypass graft surgery were
randomized to receive either N-acetylcysteine, vitamin C and selenium 600
mg, 1500 mg, 0.5 mg, and nothing orally twice a day, respectively, from the
day before to 2 days after surgery. They were assessed for the development
of acute kidney injury using Acute Kidney Injury Network criteria, time of
onse ...

Source: Brazilian Journal of Cardiovascular Surgery - June 2, 2018 Category: Cardiology Source Type: research