Effect of Ischemic Postconditioning and Atorvastatin in the Prevention of Remote Lung Reperfusion Injury

Objective: The aim of the present study was to evaluate the ability of ischemic
postconditioning, atorvastatin and both associated to prevent or minimize
reperfusion injury in the lung of rats subjected to ischemia and reperfusion
by abdominal aortic clamping.Methods: We used 41 Wistar norvegic rats, which were distributed into 5 groups:
ischemia and reperfusion (I/R), ischemic postcondictioning (IPC),
postconditioning + atorvastatin (IPC+A), atorvastatin (A) and SHAM. It was
performed a medium laparotomy, dissection and isolation of the infra-renal
abdominal aorta; except for the SHAM group, all the others were submitted to
...

Source: Brazilian Journal of Cardiovascular Surgery - June 2, 2018 Category: Cardiology Source Type: research