BMD-based assessment of local porosity in human femoral cortical bone

Cortical pores are determinants of the elastic properties and of the ultimate strength of bone tissue. An increase of the overall cortical porosity (Ct.Po) as well as the local coalescence of large pores cause an impairment of the mechanical competence of bone. Therefore, Ct.Po represents a relevant target for identifying patients with high fracture risk. However, given their small size, the in vivo imaging of cortical pores remains challenging. The advent of modern high-resolution peripheral quantitative computed tomography (HR-pQCT) triggered new methods for the clinical assessment of Ct.Po at the peripheral skeleton, either by pore segmentation or by exploiting local bone mineral density (BMD).

Source: Bone - May 31, 2018 Category: Orthopaedics Authors: Gianluca Iori, Frans Heyer, Vantte Kilappa, Caroline Wyers, Peter Varga, Johannes Schneider, Melanie Gr äsel, Robert Wendlandt, Reinhard Barkmann, Joop van den Bergh, Kay Raum Tags: Full Length Article Source Type: research