MicroRNA-mediated immune regulation in rheumatic diseases

MicroRNAs (miRNAs) are endogenous small, non-coding RNAs that regulate genome expression at the post-transcriptional level. They are involved in a wide range of physiological processes including the maintenance of immune homeostasis and normal function. Accumulating evidence from animal studies show that alterations in pan or specific miRNA expression would break immunological tolerance, leading to autoimmunity. Differential miRNA expressions have also been documented in patients of many autoimmune disorders.
Source: Cancer Letters - Category: Cancer & Oncology Authors: Tags: Mini-review Source Type: research