(-)-Stepholidine reduces cue-induced reinstatement of cocaine seeking and cocaine self-administration in rats

Drug use is a prevalent problem in the United States; in 2016 roughly 1.9 million people aged 12 or older were current users of cocaine (Center for Behavioral Health Statistics and Quality, 2017). Cocaine addiction is classified as a maladaptive cycle of use (often binge-like), abstinence and relapse. A major obstacle in the treatment of cocaine addiction is the prevention of relapse, itself caused by craving often induced by cocaine-associated cues (Childress et al., 1988; Tiffany, 1990; O ’Brien et al., 1998).
Source: Drug and Alcohol Dependence - Category: Addiction Authors: Tags: Full length article Source Type: research