Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation
Conclusions:
Our study identified for the first time gene promoter hypomethylation as a distinctive subtype-specific mechanism for controlling the expression of a key regulator of Rac-mediated motility and metastasis in breast cancer.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Laura Barrio-RealLorena BenedettiNora EngelYaping TuSoonweng ChoSaraswati SukumarMarcelo Kazanietz Source Type: research
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