Bone microarchitecture, biomechanical properties, and advanced glycation end-products in the proximal femur of adults with type 2 diabetes

Skeletal fragility is a major complication of type 2 diabetes mellitus (T2D), but there is a poor understanding of mechanisms underlying T2D skeletal fragility. The increased fracture risk has been suggested to result from deteriorated bone microarchitecture or poor bone quality due to accumulation of advanced glycation end-products (AGEs). We conducted a clinical study to determine whether: 1) bone microarchitecture, AGEs, and bone biomechanical properties are altered in T2D bone, 2) bone AGEs are related to bone biomechanical properties, and 3) serum AGE levels reflect those in bone.

Source: Bone - May 30, 2018 Category: Orthopaedics Authors: Lamya Karim, Julia Moulton, Miranda Van Vliet, Kelsey Velie, Ann Robbins, Fatemeh Malekipour, Ayesha Abdeen, Douglas Ayres, Mary L. Bouxsein Tags: Full Length Article Source Type: research