One-Pot Synthesis and Bio-distribution of Fluorine-18 Labelled Serum Albumin for Vascular Imaging

Equilibrium single-photon radionuclide imaging methods for assessing cardiac function and the integrity of the vascular system have long been in use for both clinical and research purposes. However, positron-emitting blood pool agents that could provide PET equivalents to these (and other) clinical procedures have not yet been adopted despite technical imaging advantages offered by PET. Our goal was to develop a PET blood pool tracer that not only meets necessary in vivo biological requirements but can be produced with an uncomplicated and rapid synthesis method which would facilitate clinical translation.

Source: Nuclear Medicine and Biology - May 30, 2018 Category: Nuclear Medicine Authors: Falguni Basuli, Xiang Zhang, Mark R. Williams, Jurgen Seidel, Michael V. Green, Peter L. Choyke, Rolf E. Swenson, Elaine M. Jagoda Source Type: research