Oxytocin Receptor mRNA Expression in Dorsolateral Prefrontal Cortex in Major Psychiatric Disorders: A Human Post-mortem Study

There is growing interest in investigating the role of the nine amino acid peptide oxytocin (OT) as a pharmacologic therapy for various psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BPD) and schizophrenia(SZ)/schizoaffective disorder (Macdonald and Macdonald, 2010). This interest in oxytocin as a treatment stems from preclinical and clinical studies demonstrating the role of exogenous and endogenous OT to promote social affiliation and cognition, to improve mood and to reduce anxiety (Meyer-Lindenberg et al., 2011).

Source: Psychoneuroendocrinology - May 30, 2018 Category: Psychiatry Authors: MR Lee, MB Sheskier, M Farokhnia, N Feng, S Marenco, BK Lipska, L Leggio Source Type: research