Higher-order language dysfunctions as a possible neurolinguistic endophenotype for schizophrenia: evidence from patients and their unaffected first degree relatives.

Schizophrenia is considered to be a heritable disease acting via a polygenetic mechanism, but the complex nature of its phenotype hinders discovery of the genes responsible (Cannon, 2005; Harrison and Law, 2006; Harrison and Owen, 2003; Liu et al., 2017; Misiak et al., 2016; Rutkowski et al., 2017). In order to simplify the genetic analysis and to identify susceptibility genes, an effort has been made to identify the endophenotypes of the susceptibility genes (Braff et al., 2007; Gould and Gottesman, 2006).

Source: Psychiatry Research - May 30, 2018 Category: Psychiatry Authors: Agnieszka Pawe łczyk, Emila Łojek, Natalia Żurner, Marta Gawłowska-Sawosz, Tomasz Pawełczyk Source Type: research