Connecting Clinical Aspects to Cortico-Motor Excitability in Restless Legs Syndrome: A TMS Study

We assessed cortico-motor excitability in the primary motor cortex (M1) of participants with moderate-severe restless legs syndrome (RLS) symptoms using transcranial magnetic stimulation (TMS) in relation to the clinical and sleep aspects of the disease. Thirty-five participants (20 F; mean age 59.23 ±1.66; range 42-78) affected by primary RLS (off medications) and 31 age-matched controls (19 F; mean age 57.90±1.50; range 43-79) underwent TMS following two nights of polysomnography (PSG). Paired-pulse TMS measures [short interval cortical inhibition (SICI), long interval cortical inhibition (L ICI), and intracortical facilitation (ICF)] of the dominant M1hand and M1leg muscles were collected and analyzed in relation to clinical features of RLS and PSG.

Source: Sleep Medicine - May 30, 2018 Category: Sleep Medicine Authors: Rachel Marie E. Salas, Aadi Kalloo, Christopher J. Earley, Pablo Celnik, Tiana E. Cruz, Keyana Foster, Gabriela Cantarero, Richard P. Allen Tags: Original Article Source Type: research