BMP15 Regulates AMH Expression via the p38 MAPK Pathway in Granulosa Cells from Goat

Anti-Mullerian hormone (AMH), a member of the TGF- β superfamily, is produced by granulosa cells (GCs) of preantral and small antral follicles and plays a role in regulating the recruitment of primordial follicles and the FSH-dependent development of follicles. However, the regulation of AMH expression in follicles remains poorly understood. The ob jectives of this study were to determine the following: 1. the association between bone morphogenetic protein 15 (BMP15) and AMH; 2. whether BMP15 can regulate the expression of AMH by inhibiting the p38 MAPK pathway; and 3.

Source: Theriogenology - May 30, 2018 Category: Genetics & Stem Cells Authors: Zhongquan Zhao, Fangyue Guo, Xiaowei Sun, Qijie He, Zinuo Dai, Xiaochuan Chen, Yongju Zhao, Jian Wang Source Type: research