Commentary on “DNA damage response and repair gene alterations are associated with improved survival in patients with platinum-treated advanced urothelial carcinoma.”

Platinum-based chemotherapy remains the standard treatment for advanced urothelial carcinoma by inducing DNA damage. We hypothesize that somatic alterations in DNA damage response and repair (DDR) genes are associated with improved sensitivity to platinum-based chemotherapy.

Source: Urologic Oncology: Seminars and Original Investigations - May 30, 2018 Category: Urology & Nephrology Authors: MY Teo, RM Bambury, EC Zabor, E Jordan, H Al-Ahmadie, ME Boyd, N Bouvier, SA Mullane, EK Cha, N Roper, I Ostrovnaya, DM Hyman, BH Bochner, ME Arcila, DB Solit, MF Berger, DF Bajorin, J Bellmunt, G Iyer, JE. Rosenberg Tags: Urologic Oncology Survey Source Type: research