What about novel pathogenetic mechanisms in Multiple Sclerosis? The emerging role of mitochondria

It has been recently found that mitochondrial dysfunction may be considered as an important component of human Multiple Sclerosis (MS) lesions, playing a key role in the loss of oligodendrocytes and axons, besides other possible causal pathogenetic mechanisms [1]. Amongst these mechanisms, oxidative stress is believed to have an important role in MS pathogenesis, and therefore oxidative stress may be an effective target for MS treatment [2]. Indeed, antioxidants have been demonstrated to be effective in suppressing MS inflammation [3].

Source: Medical Hypotheses - April 12, 2018 Category: Biomedical Science Authors: Simona Portaro, Antonino Naro, Vincenzo Cimino, Rocco Salvatore Calabr ò Source Type: research