Philadelphia-like acute lymphoblastic leukemia: a review of the genetic basis, clinical features and therapeutic options

Philadelphia-like acute lymphoblastic leukemia (Ph-like ALL) is a recently identified high-risk subtype of B-lineage ALL (B-ALL), characterized by a gene expression profile similar to that of Philadelphia-positive (Ph+) ALL, but without the hallmark BCR-ABL1 oncoprotein. Ph-like ALL represents approximately 15% of childhood ALL and its frequency rises with age, peaking among adolescents and young adults with B-ALL. This subtype is associated with adverse clinical features, persistence of minimal residual disease (MRD) and a poor prognosis despite modern chemotherapy regimens.
Source: Seminars in Hematology - Category: Hematology Authors: Tags: Review Source Type: research