Therapeutic complement modulation for hematological diseases: where we stand and where we are going

Complement-mediated hemolytic anemias are a heterogeneous group of diseases which are characterized by the pathogenic involvement of the complement cascade, irrespective of different etiologies and clinical presentations. Complement-mediated hemolytic diseases can be categorized according to different criteria; we have recently proposed a tentative classification based on the type of pathogenic involvement of the complement cascade (Table  1). [1] Accordingly, complement-mediated hemolytic anemias may be grouped into: i.

Source: Seminars in Hematology - May 29, 2018 Category: Hematology Authors: Antonio M Risitano Source Type: research