All-cause mortality in older adults with affective disorders and dementia under treatment with antipsychotic drugs: A matched-cohort study

The use of antipsychotic drugs in the treatment of behavioral disturbances that are typically associated with dementia - such as psychosis, agitation, aggression, irritability, and disinhibition - has raised serious concerns regarding the safety of such therapeutic strategy. In 2005, the FDA issued a warning stating that atypical antipsychotics drugs were associated with increased mortality in comparison with placebo in people with dementia (FDA,  2005). In 2008, a similar black-box warning was issued for conventional antipsychotic drugs (FDA, 2010).

Source: Psychiatry Research - April 18, 2018 Category: Psychiatry Authors: Alejandro G. Szmulewicz, Augusto Ferraris, Agust ín Rodriguez, Lucía Campos Cervera, Macarena Lopez Gonzalez, Federico Man, Federico Angriman, Diego Martino Source Type: research