A simple method for calculating the likelihood ratio in a kinship test using X-chromosomal markers incorporating linkage, linkage disequilibrium, and mutation

X-chromosomal short tandem repeats (X-STR) are thought to be useful for personal identification and kinship tests because of their unique inheritance pattern [1]. However, the linkage and linkage disequilibrium (LD) between the loci must be taken into account to analyze multiple markers on the same chromosome [2]. This problem has caused some difficulties for probabilistic evaluation of the results of X-STR typings in forensic analysis. Despite of these difficulties, some precedent studies [3 –5] introduced analytical methods based on linkage analysis using the Lander-Green algorithm [6] and the LD model described by Kurbasic and Hössjer [7].
Source: Legal Medicine - Category: Forensic Medicine Authors: Source Type: research