Advances in diagnosis of mastocytosis and hypereosinophilic syndrome

Mastocytosis and hypereosinophilic syndrome (HES) are very rare neoplastic hematopoietic diseases. Mastocytosis is characterized by expansion and accumulation of clonal tissue mast cells in skin and/or various internal organs, while HES manifests with an increased number of eosinophils in the peripheral blood and tissue damage. These diseases represent a diagnostic challenge, since they can have overlapping clinical and pathological features. Recently, great advances in the molecular and immunophenotypic diagnosis of these two entities were achieved, contributing to the new World Health Organization (WHO) classification.
Source: Seminars in Hematology - Category: Hematology Authors: Source Type: research