Elevated hippocampal choline level is associated with altered functional connectivity in females with major depressive disorder: a pilot study

Major depressive disorder (MDD) is a severe worldwide public health problem, characterized by persistent low mood and anhedonia (Kupfer et al., 2012). Dysfunction of the limbic-cortical pathway, which dominates emotion processing and regulation, plays an important role in MDD pathophysiology (Hamilton et al., 2011; Mayberg, 2003). As one of the most influential network models of MDD, the limbic-cortical model suggests abnormal reciprocal interactions between the limbic system and the cortex in MDD, resulting in affective and cognitive abnormalities (Kaiser et al., 2015).

Source: Psychiatry Research: Neuroimaging - May 26, 2018 Category: Psychiatry Authors: Yingying Tang, Xiaoliu Zhang, Jianhua Sheng, Xuanhong Zhang, Jianye Zhang, Jiale Xu, Yajing Zhu, Junjie Wang, Tianhong Zhang, Shanbao Tong, Lipeng Ning, Manhua Liu, Yao Li, Jijun Wang Source Type: research