Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1

SIRT1, an NAD+-dependent histone/protein deacetylase, has diverse physiological actions. Recent studies have demonstrated that SIRT1 is overexpressed in colorectal cancer, suggesting its oncogenic potential. However, the molecular mechanisms by which overexpressed SIRT1 induces the progression of colorectal cancer and its inhibition remain largely unknown. Curcumin (diferuloymethane), a major component of the spice turmeric derived from the plant Curcuma longa L., has been reported to exert chemopreventive and anti-carcinogenic effects on colon carcinogenesis.

Source: Cancer Letters - May 25, 2018 Category: Cancer & Oncology Authors: Yeon-Hwa Lee, Na-Young Song, Jinyoung Suh, Do-Hee Kim, Wonki Kim, Jihyae Ann, Jeewoo Lee, Jeong-Heum Baek, Hye-Kyung Na, Young-Joon Surh Tags: Original Articles Source Type: research