Hypocretin/orexin antagonists decrease cocaine self-administration by female rhesus monkeys

The neuropeptides hypocretin-1 and -2 or orexin-1 and orexin-2 (de Lecea et al., 1998; Sakurai et al., 1998) derive from the lateral hypothalamus and project throughout the brain (Koob, 2008). Hypocretins interact with the noradrenergic, cholinergic, serotonergic, and dopaminergic systems as well as with the hypothalamic-pituitary-adrenal (HPA) axis. In concert, these actions have been shown to modulate sleep-wake regulation, energy homeostasis, motivational activation, and stress responsivity (Carter et al., 2009; Giardino and de Lecea, 2014; Sutcliffe and de Lecea, 2002).

Source: Drug and Alcohol Dependence - May 25, 2018 Category: Addiction Authors: Richard W. Foltin, Suzette M. Evans Source Type: research