Role of Myeloid Lineage Cell Autophagy in Ischemic Brain Injury [Basic Sciences]

In this study, we investigated the roles of myeloid cell autophagy in ischemic brain injury.Methods—Focal cerebral ischemia was induced via transient middle cerebral artery occlusion in mice with autophagy-deficient myeloid lineage cells (Atg5flox/flox LysMCre+) and in their littermate controls (Atg5flox/flox). Infarct volume, neurological function, inflammatory cell infiltration, and proinflammatory cytokine expression levels were evaluated.Results—Mice lacking autophagy in myeloid lineage cells had a lower survival rate for 14 days than control mice (20% versus 70%; P

Source: Stroke - May 25, 2018 Category: Neurology Authors: Masakazu Kotoda, Hajime Furukawa, Takeshi Miyamoto, Masaaki Korai, Fumiaki Shikata, Atsushi Kuwabara, Xiaoxing Xiong, Caleb Rutledge, Rona G. Giffard, Tomoki Hashimoto Tags: Cerebral Aneurysm, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research