Therapeutic perspectives for brain metastases in non-oncogene addicted non-small cell lung cancer (NSCLC): towards a less dismal future?

The onset of Brain Metastases (BM) is proportionally greater in lung cancer than in other solid tumors (Barnholtz-Sloan et al., 2004), with significant impact on patients performance status (PS) and prognosis (Ali and Goffin, 2013). Synchronous or metachronous central nervous system (CNS) spread occurs in about 20% and 40% of Non-Small Cell Lung Cancer (NSCLC) cases, respectively (Langer and Mehta, 2005; S ørensen et al., 1988).
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Source Type: research