CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis

As a class of endogenous noncoding RNAs, circular RNAs (circRNAs) have been recently identified to regulate tumourigenesis and progression in multiple malignancies. However, the expression profiles and function of circRNAs in breast cancer metastasis are largely unknown. Here, we determined that the expression of a novel circRNA, which we named circIRAK3, was increased in metastatic breast cancer (BC) cells and predictive of BC recurrence. Gain-of-function and loss-of-function studies in BC cells demonstrated that circIRAK3 promoted cell migration, invasion and metastasis in vitro and in vivo but did not affect cell proliferation, colony formation or cell cycle progression.

Source: Cancer Letters - May 24, 2018 Category: Cancer & Oncology Authors: Jie Wu, Zerun Jiang, Chen Chen, Qingsong Hu, Ziyi Fu, Junjie Chen, Zhangding Wang, Qiang Wang, Aiping Li, Jeffrey R. Marks, Changying Guo, Yun Chen, Jianwei Zhou, Liuqing Yang, Chunru Lin, Shouyu Wang Tags: Original Articles Source Type: research