Resveratrol interrupts the pro-invasive communication between Cancer Associated Fibroblasts and Cholangiocarcinoma cells

Cholangiocarcinoma (CCA), the cancer arising from the epithelial cells of bile ducts, is a prototype of inflammatory-driven cancer. Cytokines released by cancer associated fibroblasts (CAFs) play a pivotal role in CCA progression, driving the epigenetic Epithelial-to-Mesenchymal transition and the growth and metastasization of CCA cells. Consistently, the conditioned medium from CCA-derived CAFs further stimulated the secretion of IL-6, and to a lesser extent of IL-8, by CCA cells. CCA has a poor prognosis, because of late diagnosis and of high resistance to radio- and chemo-therapy of CCA cells.

Source: Cancer Letters - May 23, 2018 Category: Cancer & Oncology Authors: Suyanee Thongchot, Alessandra Ferraresi, Chiara Vidoni, Watcharin Loilome, Puangrat Yongvanit, Nisana Namwat, Ciro Isidoro Tags: Original Articles Source Type: research