T1, diffusion tensor, and quantitative magnetization transfer imaging of the hippocampus in an Alzheimer's disease mouse model

Alzheimer's disease (AD) pathology causes microstructural changes in the brain. These changes, if quantified with magnetic resonance imaging (MRI), could be studied for use as an early biomarker for AD. The aim of our study was to determine if T1 relaxation, diffusion tensor imaging (DTI), and quantitative magnetization transfer imaging (qMTI) metrics could reveal changes within the hippocampus and surrounding white matter structures in ex vivo transgenic mouse brains overexpressing human amyloid precursor protein with the Swedish mutation.

Source: Magnetic Resonance Imaging - March 12, 2018 Category: Radiology Authors: Heather T. Whittaker, Shenghua Zhu, Domenico L. Di Curzio, Richard Buist, Xin-Min Li, Suzanna Noy, Frances K. Wiseman, Jonathan D. Thiessen, Melanie Martin Tags: Original contribution Source Type: research